Evaluation of Antibacterial and Antifungal Activity of New derivatives of two, three and four components of ۱, ۳, ۴-oxadiazoles

سال انتشار: 1399
محل انتشار: بیست و یکمین کنگره ملی و نهمین کنگره بین المللی زیست شناسی ایران
کد COI اختصاصی: BIOCONF21_0861
زبان مقاله: انگلیسی
تعداد مشاهده: 155

نویسندگان

Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

چکیده

The emergence of antibiotic resistance in the treatment of diseases has become a serious problem; therefore, in the current situation, the discovery and presentation of alternative structures is very important. The aim of this study was to investigate the new ۱, ۳, ۴-oxadiazole structures against bacteria and fungi resistant to treatment. Twelve new derivatives were obtained by single-step synthesis and their structure was evaluated by IR (Infrared), C-NMR (Carbon Nuclear Magnetic Resonance) and H-NMR (Hydrogen Proton Nuclear Magnetic Resonance).Then, to measure the antibacterial and antifungal activity of prepared derivatives agar well diffusion method was employed, and the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined at a concentration of ۰.۱mg/mL with three replications on Streptococcus Mutans, Enterococcus Faecalis, Klebsiella Pneumoniae, Escherichia Coli O۱۵۷: H۷, Candida Glabrata, Candida Krusei. Statistical analysis of the data was performed using (IBM SPSS Statistics ۲۲). The results showed that the best antibacterial activity among all compounds was related to the ۴g compound against the E.faecalis (IZ= ۴۵.۳۳ ± ۱.۱۵ mm), (MIC: ۲۵۰μg /ml), that showed inhibition zones greater than the control.The compound (۴g) also showed acceptable activity on the S. mutans (IZ= ۲۵.۶۶ ± ۰.۵۷ mm) (MIC: ۱۲۵ μg/ml), and other bacteria were affected too .In the case of fungal specimens, no acceptable results were obtained. Based on the results of this study, the compound ۴g (with the chlorophenyl and morpholine functional groups) can be used as an alternative to the ability to inhibit gram-positive bacteria resistant to antibiotics.

کلیدواژه ها

Antibiotic Resistance, Enterococcus faecalis, Streptococcus mutans, chlorophenyl, morpholine

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.