Thermo-responsive TiO۲-poly (N-isopropylacrylamide) Nanocarrier serving as a smart doxorubicin delivery system

سال انتشار: 1400
محل انتشار: هفتمین کنفرانس بین المللی فناوری های نوآورانه در زمینه علوم، مهندسی و تکنولوژی
کد COI اختصاصی: TETSCONF07_002
زبان مقاله: انگلیسی
تعداد مشاهده: 265

نویسندگان

Shahid Beheshti University, Tehran, Iran

Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

چکیده

Designing of a smart drug delivery system for cancer cell targeting is always a hot topic in life science research. Titanium dioxide (TiO۲) as a cost-effective and non-toxic nano structure with high functional surface and photo catalytic activity has been used in cancer drug delivery system. In other hand, recently, poly(N-isopropylacrylamide) (PNIPAM)-based smart hydrogels which could stimulated by a slight change in temperature to give a significant swelling/deswelling process and lead to phase transition at a lower critical solution temperature (LCST) has gain much attention. In pursuit of design thermo-responsive polymeric nanocarrier for sustained delivery of doxorubicin (DOX) drug, TiO۲-poly (N-isopropylacrylamide) hybrid was prepared using controlled polymerization technique known as reversible addition fragmentation chain transfer (RAFT) polymerization. The accuracy of the synthesized polymer nano composite data has been confirmed by Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Calorimetric Analysis (TGA) and X-ray powder diffraction (XRD). Subsequently, the thermo-responsive behavior of the PNIPAM/TiO۲ was investigated by UV–Vis spectroscopy. DOX was successfully loaded into the PNIPAM/TiO۲ nanogel and release pattern of nanodrug carrier was assessed in the simulated medium of healthy organs or cancer tissue with ۳۷ and ۴۲°C. Finally, the cytotoxicity assay will be performed on breast cancer/MCF-۷ cell line to determine potential of nanodrug carrier as a highly intelligent anti-cancer agent.

کلیدواژه ها

TiO۲-poly (N-isopropylacrylamide) ،nanocarrier, smart delivery system، doxorubicin ،MTT assay

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.