The bidirectional effect of prelimbic ۵-hydroxytryptamine type-۴ (۵-HT۴) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats
- سال انتشار: 1400
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 6
- کد COI اختصاصی: JR_IJBMS-24-6_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 271
نویسندگان
Institute for Cognitive Science Studies, Tehran, Iran
Department of Pharmacology, School of Medicine and Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Cognitive and Neuroscience Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Institute for Cognitive Science Studies, Tehran, Iran
چکیده
Objective(s): This study aimed at investigating the effect of serotonergic ۵-HT۴ receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB۱ cannabinoid receptor agonist) in the pre-limbic (PL) cortex. Materials and Methods: We used the step-through passive avoidance test to evaluate memory consolidation of male Sprague-Dawley (SD) rats. Bilateral post-training microinjections of the drugs were done in a volume of ۰.۶ μl/rat into the PL area (۰.۳ μl per side).Results: The results showed a significant interaction between RS۶۷۳۳۳ hydrochloride (۵-HT۴ receptor agonist) or RS۲۳۵۹۷-۱۹۰ hydrochloride (۵-HT۴ receptor antagonist) and ACPA on consolidation of aversive memory. RS۶۷۳۳۳ hydrochloride (۰.۵ μg/rat) enhanced consolidation of memory and its co-administration at the ineffective dose of ۰.۰۰۵ μg/rat with ineffective (۰.۰۰۱ μg/rat) or effective (۰.۱ μg/rat) doses of ACPA improved and prevented impairment of memory caused by ACPA, respectively. In other words, RS۶۷۳۳۳ had a bidirectional effect on ACPA-caused amnesia. While RS۲۳۵۹۷-۱۹۰ hydrochloride had no effect on memory at the doses used (۰.۰۰۵, ۰.۰۱, ۰.۱, or ۰.۵ μg/rat); but its concomitant use with an effective dose of ACPA (۰.۱ μg/rat) potentiated amnesia. None of the drugs had an effect on locomotor activity.Conclusion: This study revealed that activation or deactivation of the ۵-HT۴ receptors in the PL may mediate the IA memory impairment induced by ACPA indicating a modulatory role for the ۵-HT۴ serotonergic receptors.کلیدواژه ها
ACPA, Pre-limbic cortex, Passive avoidance memory, RS۲۳۵۹۷-۱۹۰, RS۶۷۳۳۳اطلاعات بیشتر در مورد COI
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