The bidirectional effect of prelimbic ۵-hydroxytryptamine type-۴ (۵-HT۴) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 251

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شناسه ملی سند علمی:

JR_IJBMS-24-6_003

تاریخ نمایه سازی: 17 خرداد 1400

چکیده مقاله:

Objective(s): This study aimed at investigating the effect of serotonergic ۵-HT۴ receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB۱ cannabinoid receptor agonist) in the pre-limbic (PL) cortex. Materials and Methods: We used the step-through passive avoidance test to evaluate memory consolidation of male Sprague-Dawley (SD) rats. Bilateral post-training microinjections of the drugs were done in a volume of ۰.۶ μl/rat into the PL area (۰.۳ μl per side).Results: The results showed a significant interaction between RS۶۷۳۳۳ hydrochloride (۵-HT۴ receptor agonist) or RS۲۳۵۹۷-۱۹۰ hydrochloride (۵-HT۴ receptor antagonist) and ACPA on consolidation of aversive memory. RS۶۷۳۳۳ hydrochloride (۰.۵ μg/rat) enhanced consolidation of memory and its co-administration at the ineffective dose of ۰.۰۰۵ μg/rat with ineffective (۰.۰۰۱ μg/rat) or effective (۰.۱ μg/rat) doses of ACPA improved and prevented impairment of memory caused by ACPA, respectively. In other words, RS۶۷۳۳۳ had a bidirectional effect on ACPA-caused amnesia. While RS۲۳۵۹۷-۱۹۰ hydrochloride had no effect on memory at the doses used (۰.۰۰۵, ۰.۰۱, ۰.۱, or ۰.۵ μg/rat); but its concomitant use with an effective dose of ACPA (۰.۱ μg/rat) potentiated amnesia. None of the drugs had an effect on locomotor activity.Conclusion: This study revealed that activation or deactivation of the ۵-HT۴ receptors in the PL may mediate the IA memory impairment induced by ACPA indicating a modulatory role for the ۵-HT۴ serotonergic receptors.

نویسندگان

Nargol Ahmadi-Mahmoodabadi

Institute for Cognitive Science Studies, Tehran, Iran

Masoumeh Emamghoreishi

Department of Pharmacology, School of Medicine and Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Nasehi

Cognitive and Neuroscience Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Mohammad-Reza Zarrindast

Institute for Cognitive Science Studies, Tehran, Iran

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  • Green AR. Neuropharmacology of ۵‐hydroxytryptamine. Br J Pharmacol ۲۰۰۶; ۱۴۷:S۱۴۵-S۱۵۲ ...
  • Dhonnchadha BÁN, Cunningham KA. Serotonergic mechanisms in addiction-related memories. Behav ...
  • Haj-Dahmane S, Shen RY. Modulation of the serotonin system by ...
  • King MV, Marsden CM, Fone KCF. A role for the ...
  • Bockaert J, Claeysen S, Compan V, Dumuis A. ۵-HT۴ Receptors. ...
  • Murphy SE, Wright LC, Browning M, Cowen PJ, Harmer CJ. ...
  • Cai X, Flores-Hernandez J, Feng J, Yan Z. Activity-dependent bidirectional ...
  • Perez-Garcia G, Meneses A. Memory formation, amnesia, improved memory and ...
  • Ahmad I, Nirogi R. ۵-HT۴ Receptor agonists for the treatment ...
  • Orsetti M, Dellarole A, Ferri S, Ghi P. Acquisition, retention, ...
  • Lucas G, Compan V, Charnay Y, Neve RL, Nestler EJ, ...
  • Feng J, Cai X, Zhao JH, Yan Z. Serotonin receptors ...
  • Euston DR, Gruber AJ, McNaughton BL. The role of medial ...
  • Vertes RP. Interactions among the medial prefrontal cortex, hippocampus and ...
  • Stern CAJ, Gazarini L, Vanvossen AC, Hames MS, Bertoglio LJ. ...
  • Sotres-Bayon F, Sierra-Mercado D, Pardilla-Delgado E, Quirk GJ. Gating of ...
  • Zhang Y, Fukushima H, Kida S. Induction and requirement of ...
  • Lichtman AH, Varvel SA, Martin BR. Endocannabinoids in cognition and ...
  • Tan H, Lauzon NM, Bishop SF, Chi N, Bechard M, ...
  • Egerton A, Allison C, Brett RR, Pratt JA. Cannabinoids and ...
  • Maejima T, Masseck OA, Mark MD, Herlitze S. Modulation of ...
  • Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, ...
  • Hermann H, Marsicano G, Lutz B. Coexpression of the cannabinoid ...
  • Ferreira SG, Teixeira FM, Garcao P, Agostinho P, Ledent C, ...
  • Balazsa T, Biro J, Gullai N, Ledent C, Sperlagh B. ...
  • Aso E, Renoir T, Mengod G, Ledent C, Hamon M, ...
  • Tzavara ET, Davis RJ, Perry KW, Li X, Salhoff C, ...
  • Zavitsanou K, Wang H, Dalton VS, Nguyen V. Cannabinoid administration ...
  • Moranta D, Esteban S, Garcia-Sevilla JA. Chronic treatment and withdrawal ...
  • Best AR, Regehr WG. Serotonin evokes endocannabinoid release and retrogradely ...
  • N.R.C. Guide for the Care and Use of Laboratory Animals. ...
  • Paxinos G, Watson C. The rat brain in stereotaxic coordinates. ...
  • Rasekhi K, Oryan S, Nasehi M, Zarrindast MR. Involvement of ...
  • Ahmadi-Mahmoodabadi N, Nasehi M, Emam Ghoreishi M, Zarrindast M-R. Synergistic ...
  • Ogren SO, Stiedl O. Passive Avoidance. Encyclopedia of Psychopharmacol ۲۰۱۵:۱۲۲۰-۱۲۲۸ ...
  • Ueki A, Miwa Ch, Miyoshi K. Impairment in the acquisition ...
  • Chegini HR, Nasehi M, Zarrindast MR. Differential role of the ...
  • Lamirault L, Simon H. Enhancement of place and object recognition ...
  • Meneses A. Stimulation of ۵-HT۱A, ۵-HT۱B, ۵-HT۲A/۲C, ۵-HT۳ and ۵-HT۴ ...
  • Freret T, Bouet V, Quiedeville A, Nee G, Dallemagne P, ...
  • Nasehi M, Davoudi K, Ebrahimi-Ghiri M, Zarrindast M-R. Interplay between ...
  • Nasehi M. The modulatory effect of CA۱ ۵HT ۴ receptors ...
  • Polter AM, Li X. ۵-HT۱A receptor-regulated signal transduction pathways in ...
  • Bockaert J, Claeysen S, Compan V, Dumuis A. ۵-HT۴ receptors: ...
  • Steven CL, Yan L, Alan LP, Elena D, Gennady S, ...
  • Seyedabadi M, Fakhfouri G, Ramezani V, Mehr SE, Rahimian R. ...
  • Pytliak M, Vargova V, Mechirova V, Felsoci M. Serotonin receptors ...
  • Coupar IM, Desmond PV, Irving HR. Human ۵-HT۴ and ۵-HT۷ ...
  • Claeysen S, Sebben M, Becamel C, Bockaert J, Dumuis A. ...
  • Pindon A, Hecke GV, Gompel PV, Lesage AS, Leysen JE, ...
  • Ji LL, Peng JB, Fu CH, Cao D, Li D, ...
  • Zhang Y, Lu W, Wang Z, Di Z, Wang G, ...
  • Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD. ...
  • Bonhaus DW, Loury DN, Jakeman LB, Hsu SA, To ZP, ...
  • Wawra M, Fidzinski P, Heinemann U, Mody I, Behr J. ...
  • Eriksson T, Delagrange P, Spedding M, Popoli M, Mathé A, ...
  • Matsumoto M. Evidence for involvement of central ۵-HT۴ receptors in ...
  • Shen F, Smith JAM, Chang R, Bourdet DL, Tsuruda PR, ...
  • Lelong V, Lhonneur L, Dauphin F, Boulouard M. BIMU ۱ ...
  • Micale V, Leggio GM, Mazzola C, Drago F. Cognitive Effects ...
  • Nasehi M, Kafi F, Khakpai F, Zarrindast MR. Involvement of ...
  • Zarate J, Churruca I, Echevarria E, Casis L, De Jesus ...
  • Daubert EA, Condron BG. Serotonin: A regulator of neuronal morphology ...
  • Oz M. Receptor-independent actions of cannabinoids on cell membranes: Focus ...
  • Hudson BD, Hébert TE, Kelly ME. Ligand- and heterodimer-directed signaling ...
  • Busquets-Garcia A, Bains j, Marsicano G. CB۱ Receptor signaling in ...
  • Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, ...
  • Kumar KK, Shalev-Benami M, Robertson MJ, Hongli Hu, Banister SD, ...
  • Bosier B, Muccioli GG, Hermans E, Lambert DM. Functionally selective ...
  • Heifets BD, Chevaleyre V, Castillo PE. Interneuron activity controls endocannabinoid ...
  • Celada P, Puig MV, Artigas F. Serotonin modulation of cortical ...
  • Søberg K, Moen LV, Skålhegg BS, Laerdahl JK. Evolution of ...
  • Turu G, Szlo L, Hunyady L. Signal transduction of the ...
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