Ginger Supplementation in Adjunct with Non-surgical Periodontal Therapy Improve Biomarkers of Stress Oxidative, Metabolic Factors and Periodontal Indices in Patients with Type 2 Diabetes Mellitus (DM) and Chronic Periodontitis. A Double-Blind, Placebo-Controlled Trial

  • سال انتشار: 1399
  • محل انتشار: اولین کنگره سالیانه دانشجویی آوان
  • کد COI اختصاصی: AVAN01_007
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 214
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نویسندگان

Hadi Bazyar

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Ahmad Zare Javid

Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Hasan Gholinezhad

Health research institute, Diabetes research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran.

Homeira Rashidi

Health research institute, Diabetes research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran.

Parvin Salehi

Dept.of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mohammad Hosein Haghighi-zadeh

Department of Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran

چکیده

Background: The objective of this study was to investigate the effects of ginger supplementation in adjunct with non-surgical periodontal therapy (NSPT) on biomarkers ofstress oxidative, metabolic and periodontal parameters in patients with type 2 DM (T2DM) and chronic periodontitis (CP). Methods: In this double-blind clinical trial study, 50 T2DM patients with CP were randomly allocated to intervention and control groups and received either 2g ginger or placebo (4 tablets) twice a day for 8 weeks. All subjects underwent NSPT during the intervention period. Fasting blood glucose (FBG), glycosylated hemoglobin levels (HbA1c), triglyceride (TG), total cholesterol (CHOL), high-density (HDL-c) and low-density lipoprotein (LDL-c) cholesterol, very low-density lipoprotein (VLDL-c), Total antioxidant capacity (TAC), Malondialdehyde (MDA), clinical attachment loss (CAL), Pocket depth (PD), plaque index and bleeding on probing (BOP) were measured in all subjects at baseline and post-intervention. Independent sample t-test was used to compare the results between two groups. Paired sample t-test was also used to compare the results within groups post-intervention. Results: A significant reduction (p < 0.05) was observed in the mean levels of HbA1c, FBG, MDA, CAL and PD in the intervention group post-intervention. There were no significant differences found in the mean levels of TG, CHOL, LDL-C, VLDL, TAC, plaque and BOP in intervention group post-intervention. The mean serum levels of HDL were significantly increased in the intervention group post-intervention (p < 0.05). There were significant differences observed in the mean changes of HbA1c (-0.75 ± 1.17 and -0.16 ± 0.44; P = 0.04),HDL (3.95 ± 8.54 vs -0.76 ± 5.04; P = 0.03), CAL (-0.57 ± 0.50 vs -0.14 ± 0.35; P = 0.003) and PD (-0.52 ± 0.51 vs - 0.19 ± 0.51; P = 0.04) between intervention and control groups after the intervention. Conclusion: It is recommended that ginger supplementation along with NSPT may be effective in control of the glycemic, lipid, antioxidant and periodontal status in T2DM with CP.

کلیدواژه ها

Type 2 diabetes mellitus; Periodontal disease; Ginger; Lipid profile; Glycemic control; Antioxidant status.

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