Nutrigenomics studies and Evaluation of Irisin level Affected by the Expression of Skeletal Muscle Genes
- سال انتشار: 1399
- محل انتشار: کنگره بین المللی علوم زیست پزشکی اصفهان
- کد COI اختصاصی: ICIBS01_195
- زبان مقاله: انگلیسی
- تعداد مشاهده: 454
نویسندگان
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Department of Genetic, School of Science, Shahr-e-kord University, Shahr-e-Kord, Iran
چکیده
Introduction: The point view of nutrigenomics, foods have signals that can affect metabolic pathways, control of homeostasis, gene expression, and protein production. Irisin production is a metabolic pathway that results from the proteolytic breakdown of the FNDC5 (Fibronectin type III domain containing 5) which is secreted by the skeletal muscle as an exercise hormone during exercise and is dependent on PGC-1 gene expression. The aim of this study is to review the effects of diet on the expression of some genes and the production of skeletal muscle proteins.Description: In studies effects of diets on skeletal muscle genes expression, Rats were fed with high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD). They were evaluated of lipid profile, FNDC5 and PGC-1 expression in muscle and protein levels of Irisin. The results showed that HFD and HCD were associated with decreased of FNDC5, PGC-1 and Irisin level. HPD prevented reductions of FNDC5, PGC-1 expression and Irisin levels, compared to the control group. although no differences were observed for total cholesterol and HDL levels.Discussion and conclusion: The molecular structure of a food can have important effects on gene expression, protein, and metabolism and enable specific signaling pathways. so small changes in structure of food have a profound effect on the sensitive pathways that are activated. In conclusion, it was found that the HPD type of diet can effective on mRNA of muscle cells and change FNDC5, PGC-1 expression and Irisin levels. Therefore, HPD seems to be the most appropriate diet to achieve high levels of irisin and thermogenesis and today, using the HPD diet is a good strategy for treat obesity and as a protein supplements in athletes diet it improve their performance.کلیدواژه ها
مقالات مرتبط جدید
- تاثیر تاریخ کاشت و رقابت جمعیت های یولاف وحشی زمستانه (.(Avena ludoviciana Dur بر مراحل فنولوژی گندم
- اثر خاکدهی پای بوته بر تغییرات مکانی کاتوس(.(Cynanchum acutum L در مزارع نیشکر
- تاثیر خاکپوش کاه و کلش گندم و علف کش لینورون بر کنترل علف هرز چچم سخت (Lolium rigidum Gaudin)در رازیانه (Foeniculum vulgare Mill.)
- بررسی کارایی روشهای مختلف کنترل علف های هرز مزارع توت فرنگی استان کردستان
- استفاده از خاکپوش زنده جهت کنترل غیرشیمیایی علف های هرز و تولید روغن با کیفیت بالا در سیاهدانه (.(Nigella sativa L
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.