Effect of Royal jelly on β-Amyloid -induced learning and memory impairment in rats

Background and Aim : Alzheimer s disease is a neurodegenerative disorder that is associated with impaired memory and cognitive functions. Royal Jelly (RJ) is a substance secreted by worker bees and has antioxidant, anti-inflammatory and anti-apoptotic pharmacological roles. These properties are important in the treatment of neurodegenerative diseases. Therefore, in this study the effects of RJ on Alzheimer s animal model were investigated.Methods : 50 Wistar male rats were divided into 5 groups including Control group, sham group, Alzheimer group and Alzheimer+ Royal jelly groups. the Alzheimer group received ICV injection of Aβ(1-40). Royal jelly(50 and 100 mg / kg) was administered daily by oral gavage for 4 weeks. Passive avoidance learning tests were performed after period of treatment. The statistical analysis of data was performed using ANOVA followed by Tukey s post hoc analysisResults : Alzheimer group showed marked enhancement in STLr(p<0.05) and TDC(p<0.001). Administration of royal jelly in both doses ameliorated the effects of beta amyloid on animal behavior in the passive avoidance learning and memory task(p<0.001).Conclusion : Our results indicate that impairments of learning and memory in beta amyloid -received rats can be inhibited by antioxidants such as royal jelly.

کلیدواژه ها:

Alzheimer ، amyloid beta ، royal jelly ، memory ، rat