Charcot arthropathy and acro-osteolysis in a ۵-year-old girl with hereditary sensory and autonomic neuropathy type II: A case report
محل انتشار: فصلنامه تحقیقات روماتولوژی، دوره: 9، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 56
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شناسه ملی سند علمی:
JR_RHRE-9-1_007
تاریخ نمایه سازی: 14 بهمن 1402
چکیده مقاله:
Charcot neuropathic arthropathy is a destructive process that can occur in patients with neuropathy associated with medical diseases such as diabetes. A rare cause of neuropathic arthropathy is congenital insensitivity to pain (CIP) which includes varying degrees of sensory loss and lack of pain perception contributing to absent withdrawal responses. The clinical manifestations of CIP include delayed diagnosis of fractures, joint dislocations, acro-osteolysis, avascular necrosis, osteomyelitis, heterotopic ossification, and Charcot arthropathy. We herein report a case of Charcot arthropathy of ankle joints in a ۵-year-old girl with CIP due to underlying hereditary sensory and autonomic neuropathy who had recurrent upper and lower limb fractures with acro-osteolysis. She had an inability to perceive pain from the first year of her life. She also had mild developmental delay. Family history was unremarkable. Blood count, liver and thyroid function tests, erythrocyte sedimentation rate, C-reactive protein, blood electrolytes, blood sugar and other laboratory tests were normal. Charcot neuropathic arthropathy in children is rare and can be a part of congenital diseases like CIP. A high degree of suspicion may lead to early detection and can prevent joint and bone destruction and deformities
کلیدواژه ها:
arthropathy ، Hereditary sensory and autonomic neuropathy ، Congenital insensitivity to pain ، Neuroarthropathy ، Acro-osteolysis
نویسندگان
Kamila Hashemzadeh
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Nima Zafari
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahla Velayati
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammadhassan Jokar
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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