Crucial role of corticotropin-releasing hormone, corticotropin-releasing hormone -binding protein, mir-۲۰۰c, and mir-۱۸۱a in preterm delivery: A case-control study

Background: Preterm birth before ۳۷th wk of gestation is called premature birth. Corticotropin-releasing hormone (CRH) and CRH-binding protein (BP) act on various maternal and fetal tissues during pregnancy, such as the myometrium, which regulates the transition from the dormant phase of the uterus to the active phase. Studies have shown that mir-۲۰۰c and mir-۱۸۱a interact with CRH and CRH-BP. Objective: The present study aimed to investigate the expression of mir-۲۰۰c, mir-۱۸۱a, CRH, and CRH-BP in women with a history of preterm birth. Materials and Methods: In this case-control study, the gene expression level of mir-۲۰۰c, mir-۱۸۱a, CRH, and CRH-BP in placental tissue samples obtained from ۴۸ women with a history of preterm labor was assessed in the Mojibian hospital of Yazd, Iran, from January to March, ۲۰۲۳. Differences between mir-۲۰۰c, mir-۱۸۱a CRH, and CRH-BP gene expressions among cases and controls were assessed.  Results: The outcomes indicated that the expression of CRH increased with going on to the regular parturition time (p < ۰.۰۰۱). While outcomes indicated, CRH-BP decreased with going on to the regular parturition time (p < ۰.۰۰۱). In addition, the results showed that the expression of mir-۱۸۱a increased and mir-۲۰۰c decreased with approaching the normal delivery time (p < ۰.۰۰۱). Conclusion: In conclusion, the expressions of mir-۲۰۰c, mir-۱۸۱a, CRH, and CRH-BP were dissimilar in different weeks of gestation. It could be proposed to use mir-۲۰۰c, mir-۱۸۱a, CRH, and CRH-BP as biomarkers to weigh the exact delivery time, which could minimize the side effects of preterm labor for the mother and fetus.

کلیدواژه ها:

CRH ، CRH-BP ، mir-۲۰۰c ، mir-۱۸۱a ، Preterm labor. ، CRH ، CRH-BP ، miR-۲۰۰c ، miR-۱۸۱a ، زایمان زودرس.