The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-۶ in rats undergoing radiotherapy

Background and aims: One of the main potential problems of radiotherapy (RT) in breast cancer is the increase in treatment-relatedinflammation. This study aimed to investigate the effect of eight weeks of moderate-intensity aerobic training (AT) on serum levels of tumornecrosis factor α (TNF-α) and interleukin-۶ (IL-۶) in rats undergoing RT.Materials and Methods: In this experimental study, ۳۲ male rats were randomly divided into four groups of eight members including (۱)healthy control (C), (۲) AT, (۳) RT, and (۴) AT + RT groups. Rats were first anesthetized with ketamine-xylazine solution (K, ۶۰-۹۰ kg/mg;Z, ۶-۱۰ kg/mg) and then located on a Plexiglas plate with a thickness of ۱ cm. Photon beam RT was performed using X-rays with a doseof ۱۱ Gy from an Elekta compact linear accelerator (Elekta Compact ۶-MV China). AT program was performed for eight weeks, five days aweek, and one session a day for ۶۰ minutes (۷۰-۷۵% of VO۲max). Afterwards, one-way ANOVA was run to examine the research variables.Results: According to the results, TNF-α was significantly higher in the RT group compared to the C group (P = ۰.۰۰۳), whereas IL-۶ levelswere significantly lower in the AT + RT group compared to the RT group (P = ۰.۰۰۱) and the C group (P = ۰.۰۲۷). Further, the levels of thiscytokine were significantly lower in the AT group compared to the RT group (P = ۰.۰۰۶) and similarly in the RT group compared to the Cgroup (P = ۰.۰۳).Conclusion: RT led to an increase in pro-inflammatory cytokines; however, performing AT could only significantly reduce the IL-۶ levels.

کلیدواژه ها:

Radiotherapy ، Aerobic exercise ، TNF-α ، IL-۶