Design, Synthesis and Application of a Novel Nanomagnetic Functionalized Acetic Acid as a Catalyst for theSynthesis of Amidoalkyl phenols

Activity and reusability of a catalyst should be considered in designing of it. Homogenouscatalysts have higher activity than heterogeneous catalysts, but their separation and recyclingis more difficult than heterogeneous ones. On the other hand, activity of heterogeneous catalystsis low, however their separation and reusability is easy [1]. 1-Amidoalkyl-2-naphtolshave biological importance because they can be converted to 1,3-oxazine [2]. 1,3-Oxazinederivatives have pharmaceutical and biological properties such as anti-tumor, anticonvulsant,antimalarial, analgesic, antibiotic, antianginal, antirheumatic and antihypertensive [3-5].Herein, we wish to introduce [Fe3O4@SiO2@(CH2)3-im-CH2CO2H]Br as a novel nano magneticcatalyst and use it as an efficient and reusable catalyst in the synthesis of amidoalkylphenols under solvent-free condition (Fig. 1).