Combined Intratympanic and Systemic Steroid Therapy for Poor-Prognosis Sudden Sensorineural Hearing Loss
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 135
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شناسه ملی سند علمی:
JR_IJOTO-25-1_004
تاریخ نمایه سازی: 11 بهمن 1400
چکیده مقاله:
Introduction: The aim of this study was to evaluate the efficacy of combined intratympanic and systemic steroid therapy compared with systemic steroid therapy alone in idiopathic sudden sensorineural hearing loss (ISSNHL) patients with poor prognostic factors. Materials and Methods: Seventy-seven patients with sudden sensorineural hearing loss (SSNHL) who had at least one poor prognostic factor (age greater than ۴۰ years, hearing loss more than ۷۰ db, or greater than a ۲-week delay between the onset of hearing loss and initiation of therapy) were included in this study. Patients were randomized to the intervention group (combined intratympanic and systemic steroid therapy) or the control group (systemic steroid therapy alone). All patients received oral treatment with systemic prednisolone (۱ mg/kg/day for ۱۰ days), acyclovir (۲ g/day for ۱۰ days, divided into four doses), triamterene H (daily), and omeprazole (daily, during steroid treatment), and were advised to follow a low salt diet. The intervention group also received intratympanic dexamethasone injections (۰.۴ ml of ۴ mg/ml dexamethasone) two times a week for two consecutive weeks (four injections in total). A significant hearing improvement was defined as at least a ۱۵-db decrease in pure tone average (PTA). Results: Among all participants, ۴۴ patients (۵۷.۱۴%) showed significant improvement in hearing evaluation. More patients showed hearing improvement in the intervention group than in the control group (۲۷ patients (۷۵%) versus ۱۷ patients (۴۱.۴%), respectively; P = ۰.۰۰۱). Conclusion: The combination of intratympanic dexamethasone and systemic prednisolone is more effective than systemic prednisolone alone in the treatment of poor-prognosis SSNHL.
کلیدواژه ها:
نویسندگان
Shima Arastou
Otorhinolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Science, Thran, Iran.
Ardavan Tajedini
Otorhinolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Science, Thran, Iran.
Pedram Borghei
Otorhinolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Science, Thran, Iran.