Critical Comments in Biomedicine (CCB) is an electronic international review journal published semiannually by Shahid Sadoughi University of Medical Sciences. Review articles (including narrative reviews, systematic reviews, systematic review and meta-analyses, review of reviews), commentaries, hypotheses, letters to editors, and systematic review protocols written in the field of biomedicine will be considered for publication in CCB. The journal particularly welcomes review articles with null findings and updated reviews. The journal is dedicated to publishing review articles, only considering their quality without taking the manuscripts’ readership, their results and the possibility of getting citations into account. Critical Comments in Biomedicine is an open-access journal and also does not charge a publication fee.