HN-0180014_Protective Effects of Garlic Powder Consumption against Hepatic Steatosis among Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial

Introduction Emerging evidence suggests that garlic (Allium sativum L.) and its bioactive components can mitigate hepatic steatosis by the modulation of hepatic lipid metabolism. We aimed to assess the efficacy of the garlic (Allium sativum L.) administration on hepatic steatosis in patients with NAFLD.Methods: This clinical trial was conducted on adult patients with ultrasound-diagnosed NAFLD. Eligible participants were randomly assigned, with the use of the stratified blocked procedure, to receive 800 mg garlic or placebo for 15 weeks. The primary outcome was the improvement in the hepatic steatosis diagnosed by ultrasound technique after 15 weeks of intervention.Results: A total of 110 patients underwent randomization, 98 patients completed the trial. Twenty-four (57.5%) patients in the garlic group achieved improvement in the hepatic steatosis compared to eight (15.6%) patients in the placebo group with the relative risk: 3.2 (95% CI, 1.6 to 6.5; P=0.001). There were significant reductions in weight, body fat mass, serum ALT, AST, FBS, Hb A1C, total cholesterol, LDL-cholesterol, and TG concentration with the garlic intake compared to placebo (P<0.05). The results were also significant after adjusting for weight change, energy intake, and physical activity. No serious adverse effects were observed with the garlic intake.Conclusion: The intake of garlic powder was accompanied by a significant improvement in the hepatic steatosis and comorbidity related to this condition among subjects with NAFLD.

کلیدواژه ها:

Allium sativum ، Garlic ، Hepatic steatosis ، Nonalcoholic fatty liver disease