HN-00550026_Effect of Weight-Loss Diet Combined with Taurine Supplementation on Body Composition and Some Biochemical Markers in Obese Women: A Randomized Clinical Trial

Introduction: Taurine (Tau) as an endogenous non-protein and sulfuric-amino acid is contributed in various biological pathways which are included anti-inflammatory, anti-oxidation, insulin resistance inhibition and lipid profile improvement. According to some experimental and clinical studies, insulin resistance and excess body weight are associated with reduced serum level of Tau. Therefore, this study was aimed to evaluate Tau supplementation and a diet-induced weight-loss on body composition and some biochemical indices in obese women.Methods: Participants were divided randomly into intervention group (standard weight-loss group + Cap Tau 3 gr/day for 8 weeks, n = 20) and control group (standard weight-loss group + Cap Placebo for 8 weeks, n = 18). To achieve weight loss, all participants consumed an individualized weight loss diet (30% reduction in total energy requirements). Chi-square test was applied to compare categorical variables between two groups at baseline. Paired t-test and independent-sample t-test were used to analyze the parametric continuous data within and between two groups, respectively. Analysis of covariance (ANCOVA) test was applied for controlling the confounding variables.Results: At the post-intervention, mean changes of TC (p = 0.04), LDL-C (p = 0.01), leptin (p = 0.005), adiponectin (P = 0.04) and hs-CRP (P = 0.02) decreased significantly in Tau group compared with the control group. No significant results were found in mean changes of other biochemical indices between two groups.Conclusion: Tau supplementation along with a weight loss diet may be useful in improving lipid profile and adipose tissue-derived factors in obesity. However, more RCTs are needed to achieve a strong conclusion.

کلیدواژه ها:

Taurine ، Weight loss diet ، Glycaemic indices ، lipid profile ، Adipokines ، obesity