HN-00350051_The Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ inOS Network Gene Expression, Serum Levels and Clinical Symptoms
- سال انتشار: 1398
- محل انتشار: سومین همایش بین المللی تغذیه بالینی ایران
- کد COI اختصاصی: ICNC03_044
- زبان مقاله: انگلیسی
- تعداد مشاهده: 433
نویسندگان
Expert on the Supervision of Treatment, Treatment Department of Tehran University of Medical Sciences, Tehran, Iran
Amir Alam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Amir Alam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Amir Alam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Amir Alam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Introduction: One of the common Neuro-inflammatory disorders is Migraine. Human and experimental models of migraine studies have indicated the role played by COX-2/ inOS in migraine’s Neuro-inflammatory pathogenesis. COX-2 andinOS are connected and contribute to inflammation and neurogenic painin the central nervous system. Omega- 3 fatty acids curcuminand active polyphenol of turmeric have Neuro-protective and anti-inflammatory effects via different mechanisms, including the suppression of COX-2 andinOS gene expression, as well as their serum levels. The goal is to evaluate the nutrigenomic effects of ω-3 fatty acids, nano-curcumin, and a combination of the two, on neuro-inflammation and clinical symptoms in migraine patients.Methods: This study indicates the results of a clinical trial over a 2-month period, considering 74 episodic migraine patients who took ω-3 fatty acids, nano-curcumin, a combination of them, or a placebo. At the beginning and end of the trial, COX-2/inOS serum levels and the expression of COX-2/inOS (in peripheral mononuclear blood cells isolated from patients) were measured, using real-time ELISA and PCR respectively. The frequency, severity and duration of pain attacks were also recorded.Results: The findings showed that ω-3 fatty acids and nano-curcumin can affect synergistically in the down-regulation of COX-2/inOS mRNA, as well as reduce their serum levels. Moreover, the combination of ω-3 and nano-curcumin significantly reduced the frequency, severity and duration of headaches (P< 0.05).Conclusion: The current findings demonstrate that therapy with combination of ω-3 fatty acids and nano-curcumin can be considered as a new approach in migraine prevention.کلیدواژه ها
curcumin, COX-2, inOS, headache, Migraine, ω-3 fatty acidsمقالات مرتبط جدید
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