HN-01830250_The Effects of Vitamin D Supplementation on Cardiac Outcomes in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis

Introduction: In this systematic review and meta-analysis our aim was to assess the effect of vitamin D supplementation on cardiac outcomes in patients with coronary artery disease.Methods: The search terms were performed from January 2000 to January 2018, only randomized clinical trials in human subjects were considered, with no language restrictions. The electronic databases used in this study were: PubMed; Cochran library; Embase; and Scopus. Two independent expert reviewers carried out data extraction according to Cochrane recommendations.Results: Only four RCTs were found in relation to the effects of vitamin D supplementation on the coronary artery disease. In these patients, vitamin D supplementation did not have a significant effect on hs-CRP mean difference (-0.04, p=0.25), Total Cholesterol (-0.46, p=0.83), TG (0.68, p=0.89), LDL (2.08, p=0.56), and HDL (-2.59, p=0.16). However, there was a significant positive effect on Diastolic Blood Pressure (-2.96, p=0.02) and Parathyroid hormone (-14.05, p<0.001).Conclusion: Supplementation with vitamin D in coronary artery disease patients with baseline vitamin D deficiency, does improve the status of diastolic blood pressure and parathyroid hormone.