Alpha-lipoic acid and lung cancer: current knowledge and future prosperities

Background and aim: Lung cancer is the most common cancer and has the most mortali ty worldwide. The most predominant risk factors for lung cancer include smoking use of tobacco products , exposure to environmental pollutants e.g. airborne genotoxic carcinogens and, multiple genetic and epigenetic alterations. Common symptoms of lung can cer are coughing, hemoptysis, dyspnea, weight loss, fatigue, and anorexia. Current Existing treatments for lung cancer are surgery thoracotomy with lobectomy or wedge resection , radiation therapy and chemotherapy, and usually, a combination of these treatments is applied. Alpha-lipoic acid ALA is an endogenous disulfide compound synthesized in mito chondria, which binds to multi-enzyme complexes such as pyruvate dehydrogenase. ALA is mostly known for its major role in energy metabolism in mitochondria but it also has power.ful antioxidant effects Materials and method: Data of the current review was identified through a search of PubMed, Scopus, and Cochrane databases and also selected articles references by using the following search terms/keywords: Alpha-lipoic acid , lung, cancer, carcinoma, and neoplasmResults: Lipoic acid acts in multiple enzyme complexes ketoacid dehydrogenases , stabi lizing these enzyme complexes and, catalyzing the oxidative decarboxylation of alpha-keto acids such as pyruvates, aloha ketoglutarate and, branched-chain keto acids. The role of lipoic acid in these processes is essential for cell growth, oxidation of carbohydrates and amino acids, and regulating mitochondrial redox balance. alpha-lipoic acid ALA has pre ventive effects on lung cancer through anti-inflammatory and antioxidative actions. ALA can inhibit the mitochondrial formation of ROS and mitochondrial release of cytochrome C and caspase-3 activity. ALA also causes the death of cells through caspase-independent path ways by increasing expression of PAR-P1 and translocation of AIF. ALA inhibits lung cancer .cell proliferation in G1phase to S phase through the mechanism Conclusion: the review suggests that alpha-lipoic acid ALA does prevent lung cancer, and the mechanism of this action is explained by, multiple studies. Even thou more research is.needed to examine the potential role of ALD in lung and other cancer treatments

کلیدواژه ها:

Alpha lipoic acid ، lung cancer ، prevention