Comparison of Adding Neostigmine and Fentanyl to Bupivacaine in Caudal Analgesia in Pediatric Inguinal Herniorrhaphy
- سال انتشار: 1396
- محل انتشار: مجله تحقیقات بیهوشی سلولی و مولکولی، دوره: 2، شماره: 4
- کد COI اختصاصی: JR_SBMU-2-4_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 379
نویسندگان
Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: The aim of the present trial was to compare efficacy and adverse effects of neostigmine against fentanyl when used as adjuvant to bupivacaine in caudal anesthesia.Materials and Methods: A total of 140 children, aged 1-6 year scheduled to elective herniorrhaphy, were enrolled. Exclusion criteria were sacral area infection, history of allergic reactions to local anesthetics, bleeding tendency, neurological or spinal disease and lack of parent consent. Patients were assigned, using permuted block randomization method, into four groups of 35. Children in the first group received a caudal injection of 0.5 ml/kg bupivacaine 0.25% plus fentanyl 1μ/kg. The second group received 0.5 ml/kg bupivacaine 0.25% plus neostigmine 1μ/kg. Patients in the third group received 0.5 ml/kg bupivacaine 0.25% plus combination of fentanyl 1μ/kg and neostigmine 1μ/kg, and those in the fourth group only received 0.5 ml/kg bupivacaine 0.25% concentration. To assess pain intensity, Wong-Baker Scale was used. Time to first analgesic request and the dosage of analgesic agent was recorded. Data were analyzed using SPSS 17.0.Results: Significant differences were observed among groups in terms of number of patients needing analgesic (p=0.01), time to first analgesic request (p=0.005) and analgesic dose. (p=0.05) The lowest number of requests for analgesia, lowest dose of pethidine and longest time to first analgesic request were in patients receiving combination of bupivacaine, neostigmine and fentanyl.Conclusion: The present study shows that the combination of fentanyl and neostigmine, could prolong duration of analgesia, and decrease severity of pain when added to bupivacaine.کلیدواژه ها
fentanyl, neostigmine, bupivacaine, caudal anesthesiaمقالات مرتبط جدید
- Phenolic fraction concentrates supplementation ameliorates learning and memory impairments in chronically stressed streptozotocin-diabetic rats by reducing brain tumor necrosis factor-α
- Chemical composition of Prangos ferulacea (L.) Lindl., and Prangos uloptera DC. essential oils and their antifungal activities
- Effect of ethyl acetate fraction of Costus afer on glycaemic control and essential haematological and biochemical indices of streptozotocin-induced diabetic rats
- Insulin supplemented with phenolic fraction concentrates displays anxiolytic and antidepressant-like properties with reductions of oxidative brain damage in chronically stressed diabetic rats
- Evaluation of erythrocyte viability, antioxidant capacity and antiplasmodial activity induced by alkaloid extract of Phyllanthus amarus
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.