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Toll-Like Receptor 4 in Ventilator-Induced Lung Injuries: Mechanism of Disease

عنوان مقاله: Toll-Like Receptor 4 in Ventilator-Induced Lung Injuries: Mechanism of Disease
شناسه (COI) مقاله: JR_SBMU-1-1_003
منتشر شده در شماره 1 دوره 1 فصل January در سال 1395
مشخصات نویسندگان مقاله:

Bahador Bagheri - Cancer Research Center and Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran
Sajad Razavi - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Gohari - Department of Infectious Diseases, Kowsar Hopsital, Semnan University of Medical Sciences, Semnan, Ira
Sara Salarian - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Dabbagh - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

خلاصه مقاله:
Toll Like Receptors (TLRs) are pathogen recognition molecules with widespread expression in the cells and tissues. Among them, TLR4 is involved in several important diseases. TLR4 can be stimulated by endogenous ligands as well as bacteria and viruses. TLR4 stimulation on the surface of monocytes leads to production of pro-inflammatory cytokines. It is documented that mechanical ventilation with tidal volumes of 40 mL/kg is able to induce inflammation. The mechanism of action of mechanical ventilation may involve increasing in TLR2 and TLR4 expression. Here we review the current understanding about TLR4 and lung injuries in basic and clinical science.

کلمات کلیدی:
Toll-like receptor 4, ventilation, lung

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/994773/