Toll-Like Receptor 4 in Ventilator-Induced Lung Injuries: Mechanism of Disease
- سال انتشار: 1395
- محل انتشار: مجله تحقیقات بیهوشی سلولی و مولکولی، دوره: 1، شماره: 1
- کد COI اختصاصی: JR_SBMU-1-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 476
نویسندگان
Cancer Research Center and Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Infectious Diseases, Kowsar Hopsital, Semnan University of Medical Sciences, Semnan, Ira
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Toll Like Receptors (TLRs) are pathogen recognition molecules with widespread expression in the cells and tissues. Among them, TLR4 is involved in several important diseases. TLR4 can be stimulated by endogenous ligands as well as bacteria and viruses. TLR4 stimulation on the surface of monocytes leads to production of pro-inflammatory cytokines. It is documented that mechanical ventilation with tidal volumes of 40 mL/kg is able to induce inflammation. The mechanism of action of mechanical ventilation may involve increasing in TLR2 and TLR4 expression. Here we review the current understanding about TLR4 and lung injuries in basic and clinical science.کلیدواژه ها
Toll-like receptor 4, ventilation, lungمقالات مرتبط جدید
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