Efficacy of Ascorbic Acid on Reducing the Development of Contrast-Induced Nephropathy

سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 247

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شناسه ملی سند علمی:

JR_RIJO-5-1_001

تاریخ نمایه سازی: 6 اسفند 1398

چکیده مقاله:

Introduction: To assess the benefits of prophylactic ascorbic acid to reduce development of contrast-induced nephropathy (CIN)in patients undergoing percutaneous coronary interventions (PCIs).Methods: PubMed was searched with the search strategy of (vitamin C OR ascorbic acid) AND (kidney OR renal) AND (PCI OR percutaneouscoronary Intervention OR cardiac OR heart). There was no date and language restriction for the selection of the articles.All the randomized controlled trials (RCTs) which investigated the efficacy of AA on reducing the incidence of CIN were included.Totally 267 articles were found at the initial search; however, only 10 RCTs were eligible to be included. Odds ratio is presented foreach of the articles as the effect size.Conclusions: Controversial findings were reported on the efficacy of AA on reducing the CIN development; due to various limitationsof these articles, there is still great debate among the cardiology and radiology communities, which increases the need forfurther researches.

نویسندگان

Hojat Naghavi

Anesthesiologist, Department of Anesthesiology and Critical Care, Mashhad, IR Iran

Shahram Amini

Associate Professor of Anesthesiology and Critical Care, Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran