Frequency of Extend Spectrum β-Lactamases Genes among Klebsiella Pneumoniae Strains Isolated from Patients Admitted to Shahid Beheshti Hospital, Babol City, Iran
- سال انتشار: 1398
- محل انتشار: مجله بیماری و تشخیص، دوره: 8، شماره: 1
- کد COI اختصاصی: JR_IEJM-8-1_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 558
نویسندگان
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.
Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Department of Biostatistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Amirmorteza Ebrahimzadeh Namvar
Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
چکیده
Background: Regarding the emergence and increasing of multidrug-resistant strains among Klebsiella pneumoniae nosocomial isolates the therapeutic options for the treatment has been limited. The β-lactamases enzymes are the major defense of gram-negative bacteria against antibiotics. The aim of this study was to the detection ofblaCTX-M, blaSHV , and blaTEM genes among K. pneumoniae strains isolated from patients who admitted to Shahid Beheshti hospital of Babol city, Iran, in 2016. Materials and Methods: This study was conducted on 50 samples of K. pneumoniae strains isolated from hospitalized patients. Antibiotic susceptibility testing was performed by Kirby- Bauer disc diffusion method according to CLSI guidelines. The blaCTX-M, blaSHV, and blaTEM genes were detected by polymerase chain reaction method. Result: Among studied strains, the prevalence of blaCTX-M, blaSHV , and blaTEM genes were 24 (49%), 44 (88%), and 36 (72%), respectively. In this study, imipenem and nitrofurantoin were more effective than other antibiotics. Also, 100% of strains were susceptible to imipenem. Conclusions: The prevalence of antibiotic resistance genes detected in this study implies a great concern for the treatment of multidrug-resistant K. pneumonie. Hence, infection control measures, including antibacterial management and identification of resistant isolates for preventing of nosocomial outbreaks have become highlightedکلیدواژه ها
Klebsiella pneumoniae, β-Lactamases, Multidrug Resistant, PCRمقالات مرتبط جدید
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