Brain Networks and Seizure Spreading
- سال انتشار: 1398
- محل انتشار: شانزدهمین کنگره بین المللی صرع
- کد COI اختصاصی: EPILEPSEMED16_037
- زبان مقاله: انگلیسی
- تعداد مشاهده: 470
نویسندگان
professor of neurology,Epileptologist.Isfahan university of Medical sciences
چکیده
In the human brain Information transmission is a fundamentally dynamic network process.Epilepsy is characterized by disturbed dynamics that originate in a local network before spreading to other brain regions.The influence of network topology and the anatomical organization of the epileptogenic process are particularly important in the context of seizure control and epilepsy surgery.Seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. The hypersynchronous discharges that occur during a seizure may begin in a very discrete region of cortex and then spread to neighboring regions. Seizure initiation is characterized by two concurrent events: 1) high-frequency bursts of action potentials, and 2) hypersynchronization of a neuronal population. Seizure propagation, the process by which a partial seizure spreads within the brain, occurs when there is sufficient activation to recruit surrounding neurons. This leads to a loss of surround inhibition and spread of seizure activity into contiguous areas via local cortical connections, and to more distant areas via long association pathways such as the corpus callosum.The propagation of bursting activity is normally prevented by intact hyperpolarization and a region of surrounding inhibition created by inhibitory neurons. With sufficient activation there is a recruitment of surrounding neurons via a number of mechanisms. The propagation of activity in neural tissue is generally associated with synaptic transmission, but epileptiform activity in the hippocampus can propagate with or without synaptic transmission . This suggests an underlying common nonsynaptic mechanism for propagation.کلیدواژه ها
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