Side effects of stablished new antiepileptic drugs

Backgrounds: Epilepsy is considered to be among the most prevalent neurological disorders and one of most important health issues. AED at 20 years for ineffectiveness was 39.3%, for adverse events 8.0%. In contrast, some of the newer AEDs appear to produce fewer adverse cognitive effects. More studies are needed to delineate fully the relative effects of all the new AEDs to each other and to the older AEDs. Methods: the all of studies founded by search with Google motor, PubMed and Iranian indexes evaluated. Results: Gabapentin (GBP) and lamotrigine (LTG) have demonstrated fewer cognitive effects than CBZ and minimal effects compared with placebo, but sleepiness in some patients is a problem. Of the new AEDs, topiramate (TPM) appears to have the greatest cognitive side effects, but slow titration during drug initiation reduces these effects. Lamotrigine have many side effects; the most important of which is allergic reactions. The major adverse events that caused discontinue lamotrigine in a study included: cutaneous reactions in 29 cases(3%); Stevens-Johnson syndrome, and severe headache, exaggerated or induced myoclonic jerk, and other rare side effects. Recently a lot patients receive levetiracetam. One of the important side is depression, especially suicide reported frequently. I observed attempt suicide in two patients.Conclusion: the new anti epileptic drugs have the seriously adverse events; Steven Janson/TEN, depression, suicide.

کلیدواژه ها:

side effects ، levetiracetam ، suicide ، depression. Lamotrigine ، skin reactions ، cognitive effects ، topiramate ، gabapentin ، sleepiness.