Ali A. Asadi-Pooya - Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA.
Epileptology - Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Psychogenic nonepileptic seizures are commonly diagnosed at epilepsy centers. The diagnosis of PNES relies on a multidisciplinary evaluation and is usually based on different combinations of data. Recording a seizure, while under video-EEG monitoring, is the most reliable diagnostic test. The neurobiology of PNES is still poorly understood. They may be the result of neurobiological dysfunctions at specific brain networks. Treatment of PNES includes multiple phases. Fewer than 50% of newly diagnosed adults could be expected to become seizure free within five years after diagnosis.