The relationship between serum zinc and diabetic children : systematic review

Introduction: Zinc is an important trace element with a crucial role in metabolism, mainly as a cofactor of many antioxidant enzymes, necessary for metabolic processes especially in metabolism, storage and secretion of insulin. Zinc deficiency can advance to chronic inflammation and oxidative stress. These roles of zinc are all related to glucose metabolism and diabetic problems in type 1 diabetic patients. Method: We performed a systematic search in PubMed, Medline, Embase and the Cochrane libraryfor relevant case-control of the relationship between serum zinc and obesity in children (2011– 2018). Inclusion criteria included case-control study, involving young participants, No history of any malignancy, age between 6 to 16 years. Results: Among the 10 articles searched, 6 studies indicated a significant difference between serumzinc in obese and non-obese children because of the important role of zinc in insulin synthesis and function. One study showed a negative correlation between Se, Zn, GSH-Px and HbA1c levels between case and control patients. Also, 2 studies showed no association between serum zinc level and fasting blood glucose, hemoglobin A1c, or duration of disease. Another study showed no changes in zinc and chromium levels in younger type 1 diabetic subjects compared to those of control subjects. The last study showed that serum zinc in diabetic children did not differ significantly from healthy controls and were independent of blood glucose control and disease period. Conclusion : Although studies have shown different results, given the important role of zinc in the synthesis, release and storage of insulin, serum zinc levels should always be monitored in peoplewith diabetes, especially children. Adequate dietary zinc levels are essential for the development of children with type 1 diabetes.

کلیدواژه ها:

diabet ، zinc ، children