Sasan Talaneh - ph.d of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
Ali Sagaghiyani far - General Practitioner MPH- Urmia University of Medical Sciences-Urmia-Iran
Zahra Azad Kasb - Urmia University of Medical Sciences Midwifery Unit - Urmia - Iran
Noshin Ensafi aval - Urmia University of Medical Sciences nurse Unit - Urmia - Iran

Background and Aim : In modern societies, genetics and environment are increasing due to environmentaland genetic infertility. The APE1 gene is a multifunctional protein that plays a role in the repair of oxidizedor acetylated DNA (NER), including 5 exons and four introns and size 21. / 2kb on the long arm ofchromosome 3 This gene generates by hydrolyzing the 3-oxidized 3-OH DNA fragments of the normal endof the nucleotides necessary for DNA repair and single- or double-strand breaks. A218T polymorphism ofAPE1 gene in infertility in female population.Methods : Materials and Methods: In this study, 3 infertile women from Urmia city were divided as patientgroup and 4 healthy blood samples were divided into control group. Sequence of T thll I enzymes was used.Finally SPSS V.24 software was used for data analysis.Results : The mean age of the patients was 51 82 82 years. Frequency of C allele was 75% in patients and25% in T allele which was significantly correlated with its frequency (P = 0.04). Also, heterozygous (TC)genotypes were 51% (P = 0.03), while dominant homozygotes (CC) and recessive homozygotes (TT) were28% and 21%, respectively, indicating no association with disease incidence. There was also a 20%incidence of familial marriage and a woman who had a family history of cancer at 4% (P = 0.04) (CL =1.19-3.71-OR = 95%).Conclusion : According to the results of mutation in APE1 gene, A218T polymorphism causes disorder incellular control process which can be used as an identification factor.

Infertility Cancer, Mutation, Polymorphism, A218T, APE1