Study on the presence of Osteopontin and α3β1 integrin in the endometrium of diabetic rats at the time of embryo implantation

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 301

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شناسه ملی سند علمی:

DTOGIMED03_174

تاریخ نمایه سازی: 26 بهمن 1398

چکیده مقاله:

Background and Aim : Embryo implantation is a critical and multifactorial phenomenon which could beimpressed by any alteration in molecular micro construction of endometrium. The aim of the current studywas to evaluate the effects of diabetes on the Osteopontin (Opn) and α3β1integrin proteins level at the timeof endometrial receptivity.Methods : Twenty-eight female rats were divided into four groups: control, diabetic, Pioglitazone-treatedand Metformin-treated. Western blot was performed to determine the Opn and α3β1integrin proteins inrats’ endometrium at the time of implantation window. Data were analyzed by Analysis of variance(ANOVA) and p<0.05 was considered statistically significant.Results : Opn was increased significantly in the diabetic group in comparison with control (p value <0.001), Metformin-treated (p value = 0.008) and Pioglitazone-treated groups (p value < 0.001).Furthermore, the 3 1 integrin protein level in diabetic group had a significant difference in comparisonwith control (p value < 0.001), Metformin-treated (p value = 0.026) and Pioglitazone-treated groups (pvalue < 0.001).Conclusion : Opn and α3β1integrin proteins are involved in the embryo implantation and their changes indiabetic condition can affect fertility. Treatment with Pioglitazone and Metformin improved the level ofOpn and α3β1integrin proteins while pioglitazone was more effective.

نویسندگان

Fatemeh Sadat Mostafavi

Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Roshanak Aboutorabi

Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Matinfar

Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran