The relationship between fetal fraction percentile and preeclampsia in pregnancy

Background and Aim : - Background Preeclampsia is an important obstetrical complication due toanomalous placental vascular implantation in early stage of pregnancy. The aim of study is determine therelationship between cell free DNA fetal fraction percentile (ff) and preeclampsia occurrence .Situation thatinfluence the placenta can frankly show concentrations of cell-free fetal DNA in circulation of the mother,as its strongly correlated to placental problems.Methods : The study is A cross-sectional study and concluded 92 mothers that needed NIPT test fordifferent reasons as increased nuchal translucency ,high risk or intermediate screening test ,soft markerdetection in sonography,and old aged,or history of trisomy in previous pregnancy. Without past medicalhistory of preeclampsia or hypertension .Then we follow up all of them.Results : - One of 72 cases was trisomy 21 and others were normal. The case was diagnosed withamniocentesis .6 cases (5.4%) were developed preeclampsia and all of them had fetal fraction of over 13%.And 85 ( 93.4%) cases had normal pregnancy.Women that suffer from preeclampsia had a higher ff thanwomen with a ordinary pregnancy . Augmented trophoblast apoptosis and an increased maternal vascularinflammatory response ,such as Preeclampsia is related to high concentrations of cell-free fetal DNA inmaternal blood circulation.Conclusion : preeclampsia may be associated with an increase concentrations of fetal cf-DNA in the serumand high fetal fraction compared to usual pregnancies. So probably we can predict preeclampsia occurrencewith fetal fraction,but it require big studies.

کلیدواژه ها:

preeclampsia ، cell-free fetal DNA ، fetal fraction