Effects of calcium and vitamin D co-supplementation on markers of inflammation and oxidative stress in overweight and vitamin D-deficient women with polycystic ovary syndrome

  • سال انتشار: 1398
  • محل انتشار: سومین کنگره بین المللی چالش های بالینی در مامائی، زنان و نازائی
  • کد COI اختصاصی: DTOGIMED03_050
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 619
دانلود فایل این مقاله

نویسندگان

Zatollah Asemi

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences,Kashan, I.R. Iran

Fatemeh Foroozanfard

Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R.Iran

Fatemeh Naderi

Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R.Iran

Mehri Jamilian

Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran

چکیده

Background and Aim : This study was conducted to determine the effects of calcium plus vitamin Dsupplementation on inflammatory factors and biomarkers of oxidative stress among overweight vitamin Ddeficientwomen with polycystic ovary syndrome (PCOS).Methods : Methods: This randomized double-blind placebo-controlled clinical trial was performed among104 overweight vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Participants wererandomly divided into four groups. Group A received 1000 mg calcium daily and vitamin D placebo weekly(n=26), group B 50000 IU vitamin D weekly and calcium placebo daily (n=26), group C 1000 mg calciumdaily plus 50000 IU vitamin D weekly (n=26) and group D calcium placebo daily plus vitamin D placeboweekly (n=26) for 8 weeks. Fasting blood samples were taken at baseline and 8 weeks after intervention tomeasure inflammatory factors and biomarkers of oxidative stress.Results : Results: After 8 weeks, individuals taking calcium plus vitamin D supplements had greaterdecreases in homeostatic model assessment-Beta cell function (HOMA-B) score (-11.1 vs. -8.6, -3.4 and13.7, respectively, P=0.03), serum high sensitivity C-reactive protein (hs-CRP) (-948.3 vs. 802.3, -383.8and 618.2 ng/mL, respectively, P=0.04), plasma malondialdehyde (MDA) concentrations (-0.6 vs. -0.5, -0.1 and 0.6 μmol/L, respectively, P=0.009) and significant increases in plasma total antioxidant capacity(TAC) (35.2 vs. 21.1, 22.5 and -153.8 mmol/L, respectively, P=0.006) and glutathione (GSH) levels (216.0vs. 3.9, -47.5 and -160.8 μmol/L, respectively, P=0.001) compared with calcium alone, vitamin D aloneand placebo groups. Calcium plus vitamin D co-supplementation did not influence plasma NO and catalaselevels. Conclusion : Conclusion: We found that calcium plus vitamin D co-supplementation for 8 weeks amongoverweight and vitamin D-deficient women with PCOS had beneficial effects on inflammatory factor andbiomarkers of oxidative stress.

کلیدواژه ها

Calcium, vitamin D, supplementation, polycystic ovary syndrome, inflammatory factor, oxidative stress

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.