Efficacy of radiosynovectomy in the treatment of chronic knee synovitis: Systematic review and meta-analysis

سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 290

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شناسه ملی سند علمی:

JR_IRJNM-23-2_001

تاریخ نمایه سازی: 21 بهمن 1398

چکیده مقاله:

Introduction: Knee joints are commonly involved with various inflammatory and non- inflammatory rheumatic diseases. Radiosynovectomy is being used as a local therapeutic option to alleviate pain and swelling in involved joints. The present study evaluated the effectiveness of radiosynovectomy for treatment of chronic knee synovitis. Methods: Through a search of Medline and SCOPUS with (Radiosynovectomy OR radio-synovectomy OR radio synovectomy OR radiation synovectomy OR radiosynoviorthesis OR radio-synoviorthesis OR synoviorthesis OR radiochemical synovectomy OR radioisotope synovectomy ) AND (Re-188 OR Y-90 OR Sm-153 OR P-32) as key words, 9 RCTs were enrolled in the analysis. Results: The outcomes of interest were odds ratio and risk difference of improvement in the radiosynovectomy group compared to the control group. Odds ratio and risk difference for Sm-153 plus corticosteroid subgroup was 1.959[0.571-6.725, P=0.285] and 14.9% [-17.1%-47%, P=0.362] respectively. The subgroup of Y-90 plus corticosteroids showed pooled odds ratio and risk difference of 2.366[0.779-7.188, P=0.129] and 23.9% [-1.7%-49.4%, P=0.67] and in the subgroup Y-90 alone were 0.851[0.356-2.036, P=0.717] and -2.3% [-23.3%-18.7%, P=0.829], respectively. Conclusion: Combination of Y-90 colloid or Sm-153 with corticosteroids in radiosynovectomy have higher response rate compared to each of radioisotope or corticosteroid therapy alone.

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نویسندگان

Nasim Norouzbeigi

Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Rasoul Zakavi

Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Narjes-Khatoun Ayati

Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Jamshid Farahati

Thyroid Center, Institute of Radiology, Nuclear Medicine and Radiotherapy, Bottrop, Germany

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