Malignant melanoma of the male urethra: a case report
- سال انتشار: 1398
- محل انتشار: سومین کنگره ملی گزارشهای موردی بالینی
- کد COI اختصاصی: CCRMED03_365
- زبان مقاله: انگلیسی
- تعداد مشاهده: 380
نویسندگان
Medical Student, Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
MD, Department of Medical Oncology and Hematology, Iran University of Medical Sciences, Tehran, Iran
Medical Student, Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Assistant Professor of Pathology, Iran University of Medical Sciences, Tehran, Iran
چکیده
Malignant melanoma of the penis is a rare malignancy, and accounts for less than 2% of all primary penile malignant lesions. Most cases occur in 6th and 7th decades of life. Most frequently, the lesion is located on the glans(55%), followed by foreskin(28%), penile shaft(9%) and urethral meatus(8%). 5-year survival is 31%.A 52-year-old man presented to hospital with history of a lesion extruded from urethral meatus. He did not mention any complaints of pain or lower urinary tract symptoms. On physical examination, there were no remarkable findings. No palpable inguinal lymphadenopathy was found.During cystoscopy, a grayish-brown mass was detected in the urethra. The lesion was resected and specimens were sent to pathology. IHC and histopathologic findings were in favor of malignant melanoma. Spiral chest and abdominopelvic CT-scan and whole body bone scan indicated no evidence of metastasis. The patient underwent partial penectomy and bilateral inguinal lymphadenectomy therewith. Subsequent pathology examination confirmed malignant melanoma with tumor size of 2.8cm in greatest diameter, and maximum tumor (Breslow) thickness of 8mm. Tumor was classified as stage2B according to AJCC TNM staging system(T4aN0M0).Ultra-Sound imaging of kidneys, ureters, bladder, penis and testes was performed and no remarkable findings were detected. The patient underwent total body PET-CT scan and abdominopelvic MRI with and without contrast; A hypodense hyper-metabolic lesion was indicated in favor of perineal abscess. Serology, biochemistry and hematologic investigations were all normal. After surgery, interferon-therapy was started for the patient as 5,000,000 units of alpha-interferon every other day for one year. Penile melanomas are usually diagnosed late; Many might have already invaded into deep anatomical structures and inguinal lymph-nodes at the time of diagnosis. Therefore, partial or total penectomy with inguinal lymph-node dissection is the treatment of choice. Early diagnosis and surgical treatment affect clinical prognosis.کلیدواژه ها
Melanoma, Urethra, Penis, Penectomyمقالات مرتبط جدید
- بررسی تاثیر اندازه، استقلال هیئت مدیره و کیفیت کمیته های هیئت مدیره بر مسئولیت پذیری اجتماعی مرتبط با حوادث طبیعی در شرکت های پذیرفته شده در بورس اوراق بهادار تهران
- تاثیر ریسک سیستماتیک و ریسک تداوم فعالیت بر رابطه بین مسئولیت اجتماعی و نگه داشت وجه نقد
- تاثیر مدیریت اعتبارات کارآمد بر سودآوری بانک های پذیرفته شده در بورس اوراق بهادار تهران
- Antimicrobial Properties and Shear Bond Strength of Composite Used in Orthodontics Following the Addition of Curcumin-Reduced Nanographene Oxide
- Identification of Potential Glucosyltransferase Inhibitors from Cinnamic Acid Derivatives Using Molecular Docking Analysis: A Bioinformatics Study
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.