Cold agglutinin mediated autoimmune hemolytic DLBL
محل انتشار: سومین کنگره ملی گزارشهای موردی بالینی
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 284
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شناسه ملی سند علمی:
CCRMED03_304
تاریخ نمایه سازی: 20 بهمن 1398
چکیده مقاله:
Cold agglutinin disease usually develops as a result of the production of a specific immunoglobulin M auto-antibody directed against the I/i and H antigens, precursors of the ABH and Lewis blood group substances, on red blood cells. Autoimmune and lymphoproliferative disorders, Mycoplasma pneumoniae and other infections can be associated with the production of cold agglutinins. In its classic presentation with haemolytic anaemia and Raynaud s syndrome, cold agglutinin disease is usually idiopathic. Several factors play a role in determining the ability of a cold agglutinin to induce a haemolytic anaemia such as antibody concentration and temperature range, in particular the highest temperature at which antibodies interact with red blood cells.
نویسندگان
Nasim Niknam
Department of Internal Medicine, Clinical Research Development Unit, Shahid Rajaei Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Mojan Assadi
Department of Hematology and Oncology, Clinical Research Development Unit, Shahid Rajaei Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Maryam Fadaei Dashti
Emergency medicine specialist, Clinical Research Development Unit Shahid Rajaei , Educational & Medical Center, Alborz University of Medical Sciences, Karaj,Iran