First venom gland transcriptomic analysis of Iranian yellow scorpion Odonthubuthus doriae with some new findings
- سال انتشار: 1398
- محل انتشار: پانزدهمین همایش سراسری سم شناسی ایران
- کد COI اختصاصی: TOXICOLOGY15_033
- زبان مقاله: انگلیسی
- تعداد مشاهده: 431
نویسندگان
Dept. of Genetics, School of Science, Shahid Chamran University, Ahvaz, Iran
Dept. of Genetics, School of Science, Shahid Chamran University, Ahvaz, Iran
Dept. of Toxicology, School of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Dept. of Toxicology, School of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Dept. of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
چکیده
Scorpion venom contains mixture of biologic molecules including selective toxins with medical capability. Odonthubuthus doriae (O. doriae) belonged to Buthidae family of scorpions and gained more interest among Iranian dangerous scorpion since 2005. We constructed the first cDNA library to explore the transcriptomic composition of this Iranian scorpion telson. Then by used of bioinformatic software each expression sequence taq (EST) from the library analyzed and its quiddity was clear. Analysis showed that toxins (42%) had more venom transcript than other component such as antimicrobial peptides, venom peptides and cell proteins. Over 16% of transcripts didn t have any open reading frames (ORF), however their sequences showed similarity by other scorpion sequences. One EST didn t have any similarity by known scorpion peptides. For the first time; we report a comprehensive study of an Iranian scorpion with interesting and novel findings. We characterized a new putative sodium channel modifier in scorpions by some bioinformatics software, and then predicted its structure and function.کلیدواژه ها
Transcriptome analysis; cDNA library; Venom gland, Iranian scorpion Odonthubuthus doriaeمقالات مرتبط جدید
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