long non-coding RNA NONHSAG071305.2 SNPs are associated with Autism Spectrum Disorder

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 379

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شناسه ملی سند علمی:

CIGS15_576

تاریخ نمایه سازی: 13 بهمن 1398

چکیده مقاله:

Autism spectrum disorder (ASD) includes a range of complex neurodevelopmental diseases with childhood onset before 3 years old. It refers to a range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication, as well as by unique strength and differences. In the past ten years, ASD have been the most prevailing pediatric disorders and its prevalence is increasing throughout the world, with an estimated 1 in 68 eight-year-old American children affected by ASD. Long non-coding RNAs (lncRNAs) are large class of transcribed RNA molecules with a length of more than 200 nucleotides that do not encode proteins. Bioinformatics and statistical data have shown correlation between some SNPs (Single Nucleotide Polymorphisms) and increase the risk of ASD. In the present study, we have checked the most important associated genes with ASD and among them we candidate NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) gene (p-value<0.001). This kinase is a membrane bound receptor that, upon neurotrophic binding, phosphorylates itself and participate in the MAPK pathway. In the NCBI database, it was shown that this gene has the highest expression in the brain. NTRK3 has four known lncRNAs based on NONCODE database, between all of them NONHSAG071305.2 has shown association with ASD. We have found the most associated SNPs, include rs8031996, rs3870431, rs10459693 and rs10459694 based on the bioinformatics analysis. The results suggest that the SNPs in NONHSAG071305.2 gene play an important role in ASD pathogenesis and can be useful for personalized medicine applications.

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نویسندگان

Saghi Hakimi Naeini

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Zeynab Rezaei

Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Reza H. Sajedi

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran