Glutathione S-Transferase Omega Gene Polymorphism: Is a new biomarker for care HPV and cervical cancer progression

Human papillomavirus (HPV) infection is an important sexually transmitted infection worldwide. Resistance infections with different high-risk HPV genotypes may cause cervical intraepithelial neoplasia and cervical cancer. Single nucleotide polymorphisms of glutathione S-transferase omega (GSTO) 1 and 2 play an important role in cancer progression. This study aims to evaluate GSTO gene polymorphism influence on women’s susceptibility to low-risk or high-risk HPV infections and impact on their risk of cervical cancer development.Methods We examined 50 patients with cervical cancer, 43 patients who were positive for HPV, and 43 healthy individuals as negative controls. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine GSTO1 A140D and GSTO2 N142D variants in study participants. Results We found a significant difference for the 140 AD genotype, 140 D allele between the cervical cancer group; HPV genotypes 16, 18, 6; and the controls. We noted a significant difference for the 140AD/142NN combination genotype between patients in the cervical cancer group and healthy controls. There were no significant differences for the GSTO2 N142D genotype and allele frequencies between the case (ie, cervical cancer and HPV-positive) groups and the controls.Conclusion The 140AD genotype, 140 D allele, and 140 AD/142NN combination genotype seem to confer a protective property in women’s susceptibility to HPV 6, 16, 18 and 16/18 infections. However, GSTO2 N142D polymorphism is not associated with HPV infections and cervical cancer. Therefore, GSTO1 A140D gene polymorphisms likely play a role in the level of susceptibility to HPV-related cervical cancer

کلیدواژه ها:

HPV ، Cervical Cancer ، Omega Gene ، Polymorphism