Searching for novel biomarkers in autoimmune diseases
- سال انتشار: 1397
- محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره ملی ژنتیک ایران
- کد COI اختصاصی: CIGS15_167
- زبان مقاله: انگلیسی
- تعداد مشاهده: 387
نویسندگان
Student s Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
The autoimmune diseases have remained unknown in many aspects, so understanding the mechanisms involved in these diseases has recently been studied. Two of the most important diseases in this group, including lupus erythematosus and arteritis rheumatoid, have been taken into consideration because the molecular studies performed on them are relatively limited. microRNAs involved in these two diseases have not yet been studied extensively. Hence, by examining the genes involved in both diseases, important overlapping genes with important roles in the pathways related to immune system were identified. By using microRNAs databases and bioinformatics analyzes and using common pathways in two diseases and also examining the genes involved in both diseases, microRNAs targeting these genes were elucidated. The family of microRNAs 180 regulates a significant number of genes involved in the pathway related to the immune system which is likely to play an important role in the ability to deal with these two conditions. Since this study has been conducted on bioinformatics level, more research on the experimental level is recommended for researchers.کلیدواژه ها
bioinformatics approach, microRNA (miRNA), autoimmunity, lupus, SLE.مقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.