Design of novel blend of Gellan gum / polyvinyl alcohol as nanofibrous scaffold for wound dressings with appropriate mechanical properties

Background: Nanofibrous polymeric scaffolds are popular in area of advanced wound therapy. This type of wound dressing can accelerate wound healing and decrease patient hospitality. They mimic the fibrous component of the natural extracellular matrix, with high cell adhesion and proliferation. Gellan gum (GG) and polyvinyl alcohol (PVA) as a mixture of natural and synthetic-derived polymeric can increase wound healing. In advanced wound dressing engineering approaches, mechanical properties as most important feature can affect wound healing process. Material & methods: GG/ PVA nanofibrous scaffolds with different weight ratio of each component were prepared by electrospinning. Scaffolds were characterized by scanning electron microscopy (SEM) and their mechanical properties were assessed by tensile test.Results: It was showed that 1.5 wt% of GG solution can be electrospun. The fibers size was measured in nano-scale range by SEM. GG was thermally cross-linked and formed a stiff and stable structure. The results indicated that GG/PVA nanofibrous scaffold with the mass ratio of 50:50 has good mechanical properties and its fibers were in the nano-scale range.Conclusion: GG/PVA with 50/50 weight ratio could be utilized as a good candidate to enhance wound healing process

کلیدواژه ها:

Wound healing ، Nanofibrous scaffold ، Gellan gum ، Polyvinyl alcohol