Clinical evaluation of the effect of restorative topical ointment on the process of open cutaneous wound healing on diabetic children: A double-blind randomized clinical triae
- سال انتشار: 1398
- محل انتشار: دوازدهمین همایش بیماری های ارثی و غدد و متابولیسم کودکان
- کد COI اختصاصی: GDRC12_031
- زبان مقاله: انگلیسی
- تعداد مشاهده: 456
نویسندگان
Doctor
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
nSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Introduction: Diabetes is one of the health problems in the world with many complications like diabetic foot that can be resulted in gangrene and amputation, and it creates economic, and psychological problems which can reduce the quality of life.Skin lesions and complications resulting from it have a negative effect on the person s performance and have an economic burden on the country. The use of bio-materials to accelerate the process of wound healing is on the rise. Hence, this study examines the effect of biocomplex ointment on the healing of open cutaneous wounds on diabetic children.Materials & Methods: This study was clinical trial. A total of 35 patients who needed skin surgery were included in this study. This trial was done with an intraindividual model as such each patient also had his own control role. Patients with no certain underlying diseases or immunosuppressive diseases or scleroderma were included and a layer of skin with a thickness of 0.04 mm from the anterior thigh was produced with a dermatome under local analgesia with dimensions less than 4 * 4 cm. Because the wounds were not equal on day zero, the size of the wounds of each group was adjusted. The surface of the wounds is divided into two parts and treated on days 0, 4, 7 and 14 under dressing with restorative ointment and Vaseline ointment was dressed by sterile gauze in treatment and control group, respectively.Results: Those wounds treated with restorative ointment showed healing rate about 25% till day 14 while in the control group was 13% (P = 0.045), in the process of reduction of the wound size, Treatment group was accelerated than the control group (P es in pain, discomfort and itching factors. No cases of infection were seen in the two groups.Conclusion & discussion: The use of biocomplex ointment in wound healing presents a novel opportunity for accelerated wound healing, the restorative ointment is more effective in reducing the size of the wound, accelerating the wound healing process, reducing of erythema and overall physician satisfaction compared to the Vaseline ointment used routinely in graft dressings.کلیدواژه ها
Open Coutaneous Wound, Healing, biocomplex ointmentمقالات مرتبط جدید
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