Comparison of serum level of Prolactin with severity of Parkinson s disease in animal model of 6- hydroxydopamine

  • سال انتشار: 1398
  • محل انتشار: هشتمین کنگره علوم اعصاب و پایه و بالینی
  • کد COI اختصاصی: NSCMED08_494
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 594
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نویسندگان

Ali Sarbazi Golezari

Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

Roghaieh Razaghi

Biology Dept. Basic Sciences Faculty, Sciences and Research Unit, Islamic Azad University, Iran

Hossein Piri

Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Hanieh Jafari

Biology Dept. Basic Sciences Faculty, Sciences and Research Unit, Islamic Azad University, Iran

Nafiseh Rastgoo

Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

Hashem Haghdoost-Yazdi

Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

چکیده

Background and Aim : Parkinson s disease (PD) has been shown to have relationship with changing in hormones, but it is not clear whether this is either a cause for or a result of the disease. To evaluate more, we examined the serum level of prolactin in 6-hydroxydopamine (6- OHDA)- induced Parkinsonism in male rats.Methods : 6-OHDA was injected into medial forebrain bundle using stereotaxic surgery. Development and intensity of Parkinsonism were evaluated by apomorphine-induced rotational test and immunofluorescence labeling of dopaminergic (DA) neurons in substantia nigra. Blood samples were collected before the toxin and in the third and sixth weeks after that. The hormone levels were determined using Enzyme-linked immunosorbent assay (ELISA) kits.Results : The severity of rotations was different among 6-OHDA- treated rats and accordingly they were divided into two subgroups of severe and mild parkinsonian rats. Degeneration of DA neurons was observed in both subgroups but it was significantly less in mild one. Prolactin increased in both subgroups in third week after the toxin but returned to normal in sixth week. There was no association between the pre-toxin levels of this hormone with the intensity of Parkinsonism.Conclusion : Our findings indicate that 6-OHDA-induced Parkinsonism associates with increase in serum level of prolactin. Increase in prolactin was observed in rats with less DA neuronal loss. Therefore, prolactin level probably can predict death of DA neurons before the clinical signs of PD were revealed.

کلیدواژه ها

Parkinson s disease; 6- OHDA; Prolactin; dopaminergic

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