Short-term plasticity in the dentate gyrus granule cells by the activation of β-Adrenergic receptors of the Basolateral Amygdala

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 289

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شناسه ملی سند علمی:

NSCMED08_467

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Adrenergic system of the basolateral amygdala (BLA), is the main system of the brain involved in the modulating of the synaptic plasticity process through the dentate gyrus. Therefore, in this study the molecular basis of the adrenergic receptors of the BLA involvements during the short term plasticity in the dentate gyrus were investigated.Methods : The rats were injected bilaterally into the BLA, a selective beta receptor agonist, clenbuterol (15 ng/0.5μl), then the paired-pulse responses were recorded. Control rats were infused by saline at the same volume.Results : Our data indicated that the infusion of clenbuterol at 15 ng/0.5 l into the BLA area could affect short-term plasticity in the dentate gyrus (DG) region measured by paired-pulse (PP) stimulations at the long term inter pulse intervals.Conclusion : Thus, adrenergic system of the BLA might engage the short term plasticity via a postsynaptic mechanism.

نویسندگان

mOTAHAREH Rouhi Ardeshiri

Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Esmaeil Akbari

Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Simin Ehsani

Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran