Hippocampal D1- but not D2-like receptors modulate the phosphorylation of ERK in food deprivation-induced reinstatement of morphine in extinguished rats
محل انتشار: هشتمین کنگره علوم اعصاب و پایه و بالینی
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 334
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شناسه ملی سند علمی:
NSCMED08_376
تاریخ نمایه سازی: 15 دی 1398
چکیده مقاله:
Background and Aim : Reinstatement to drug abuse is the most challenging issue in the addiction field so comprehensive knowledge of the involved neurobiological mechanisms is a fundamental necessity. It is known that dopamine is complicated in the neurobiology of numerous psychiatric diseases, including addiction and it is being considered a crucial element in the brain reward system.Methods : Our behavioral results documented that the administration of dopamine receptor antagonists inhibited reinstatement of morphine in FD rats. Previous studies present the ERK pathway plays a critical role in the control of cellular responses to stress and reward. Therefore, the purpose of this study was to evaluate the effect of intra-DG administration of dopamine receptors antagonists on the phosphorylation of hippocampal ERK in the reinstatement of morphine in FD rats.Results : All groups of animals passed conditional place preference (CPP) and were bilaterally given different doses of D1- or D2-like dopamine receptors, (0.25, 1 and 4 g/0.5 l) into the DG. Each animal was immediately killed after the reinstatement phase and its hippocampus was immediately dissected out and then, p-ERK/ERK ratio was evaluated by using Western blot analysis in the DG region.Conclusion : The principal findings in this study demonstrated that intra-DG administration of the highest dose of D1 receptor antagonist could enhance the hippocampal pERK/ERK ratio in FD rats while D2 receptor antagonist failed to change this ratio.
کلیدواژه ها:
نویسندگان
Roghaye Mozafari
Department of Neuroscience, Faculty of Medicine, Iran University of medical sciences, Tehran, Iran
Abbas Haghparast
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reza Ahadi
Department of anatomy, Faculty of Medicine, Iran University of medical sciences, Tehran, Iran