The effects of Juniperus excelsa s hydroalcoholic extract on passive avoidance learning and memory in male wistar rats

  • سال انتشار: 1398
  • محل انتشار: هشتمین کنگره علوم اعصاب و پایه و بالینی
  • کد COI اختصاصی: NSCMED08_207
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 627
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نویسندگان

Tahereh Ghorbandaeipour

Department of Animal Science, Faculty of Biological Sciences, Kharazmi University, Tehran-Iran

Shahrbanoo Oryan

Department of Animal Science, Faculty of Biological Sciences, Kharazmi University, Tehran-Iran

Delaram Eslimi

Department of Animal Science, Faculty of Biological Sciences, Kharazmi University, Tehran-Iran

Adel Salari

Department of Animal Science, Faculty of Biological Sciences, Kharazmi University, Tehran-Iran

چکیده

Background and Aim : Alzheimer s disease (AD) is a progressive multifarious neurodegenerative disorder, the most common form of dementia which is associated with memory and learning disorders. Effects of herbal medicines on improvement of AD symptoms has attracted many researchers. In the present study, due to the anti-inflammatory and antioxidant properties of juniperus excelsa (JE), the effect of JE extract on the improvement of passive avoidance memory was investigated.Methods : 48 male wistar rast (200-250 gr) were used and randomly divided into six groups: control (without injection), sham (ICV injection of normal saline), beta–amyloid group (ICV injection of beta-amyloid peptide), test group (3 groups which were gavaged by JE hydroalcoholic extract in three doses of 50-100-200 mg/kg, 6 days before and 20 days after ICV injection of beta amyloid). As mentioned AD was induced by ICV injection of beta-amyloid peptide (1-40). The memory was evaluated by passive avoidance test, using Shuttle box. The step-through latency (STL) for entering the dark compartment and time spent in dark compartment (TDC) were measured.Results : The findings showed that various doses of JE extract has reduced TDC (p< 0.001) and STL has increased (p< 0.05) in test groups. Maximum effect on memory was shown in 200 mg/kg dose of extract.Conclusion : JE extract has enhancing and improving effects on Passive Avoidance Learning and Memory, due to its inflammatory and antioxidant properties.

کلیدواژه ها

Alzheimer s Disease; Beta Amyloid; Passive Avoidance Learning and Memory; Juniperus excelsa

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