Association of Serum PON1 as an Antioxidant and Depression and Anxiety in Methamphetamine-Dependent Patients

  • سال انتشار: 1398
  • محل انتشار: هشتمین کنگره علوم اعصاب و پایه و بالینی
  • کد COI اختصاصی: NSCMED08_201
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 682
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نویسندگان

Nooshin Ghavidel

Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran

Sareh Asadi

NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Jamal Shams

Behavioral Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

Fariba Khodagholi

Neuroscience Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran

Abolhassan Ahmadiani

Neuroscience Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran

چکیده

Background and Aim : Although it has been reported that methamphetamine (MA) induces brain dysfunction, increases levels of oxidative stress and psychiatric symptoms, no study has been conducted to study their correlation in MA-dependent patients. The aim of this study was evaluating the correlation of serum levels of PON1 (an antioxidant), and depression and anxiety state of MA-dependent patient.Methods : Nineteen active MA abusers and 18 control subjects were included in the study. Socio-demographic and Addiction Severity Index (ASI) questionnaires were used to determine medical, drug use and family/social status. Depression, anxiety and stress scale - 21 Items (DASS-21) questionnaire was used for evaluation of their depression, anxiety, and stress. Their blood samples were collected to measure the level of PON1 by the human enzyme-linked immunosorbent assay (ELISA) kit. The data were analyzed using Graph Pad PRISM software.Results : Results showed significantly lower levels of serum PON1and higher levels of depression/anxiety in MA abusers compared to the controls. Data analysis revealed a negative correlation between PON1 level and depression/anxiety state in studied subjects.Conclusion : Our results showed higher levels of depression/anxiety which was associated with lower levels of serum PON1 in the MA-dependent patients. Further studies need to elucidate their roles in the pathophysiology of MA addiction.

کلیدواژه ها

Anxiety, Depression, Methamphetamine, PON1, Antioxidant

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