Outcome of STN- DBS on long- term motor function of patients with advanced Parkinson Disease

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 385

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شناسه ملی سند علمی:

NSCMED08_032

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : The objective of our study was to assess UPDRS score in Parkinson Disease patients who underwent STN DBS 6 years after their surgery and to compare their UPDRS score 6 years after DBS with their score before surgery and 6 months after their operation.Methods : In this cross sectional study which was carried out at Neurology department of Rasoul-e-Akram hospital in Tehran, Iran affiliated to Iran University of Medical Sciences (IUMS) between 2008 and 2014, 37 patients with advanced Parkinson disease were enrolled using non-randomized sampling method. All of the patients underwent STN-DBS surgery and one of the patients passed out before being discharged, therefore; we started our study with 36 patients. The UPDRS III total score at pre-operative state, 6 -month follow-up and 6- year follow-up state were compared respectively using repeated-measure ANOVA.Results : 37 patients (26 Male and 10 Female) with the mean age of 50.08±3.04 ranging from 32 to 72 years underwent STN-DBS surgery. All patients were suffering from the advanced Parkinson disease with the mean period of 11.28±1.88 years. All patients except one, were followed up during six months. And 14 patients (8 Male and 6 Female) were included in a six-year follow-up. The UPDRS score measurements before surgery, at 6-month follow-up and 6-year follow-up were relatively 18.22±2.88, 12.8±3.14, 25±11.8.Significant increase in UPDRS score was observed between the pre-operative and six-year follow-up score (p<0.001).Conclusion : In conclusion, this study suggested that total UPDRS score will increase at 5 years following STN DBS and also showed that resting tremor, one of UPDRS sub-scores, will improve over time and the benefit of DBS will be persistent even after 6 years.

نویسندگان

Amir Farhang Abbasi

Medical student,medicine faculty,Iran University Of Mdical sciences,Tehran,Iran

Faeze Abbasi

Medical student,medicine faculty,Iran University Of Mdical sciences,Tehran,Iran

Rmina Rashedi

MD,Iran University Of Mdical sciences,Tehran,Iran