SEXUAL DYSFUNCTION MECHANISM IN METHADONE MAINTENANCE PATIENTS

  • سال انتشار: 1398
  • محل انتشار: سیزدهمین کنگره بین المللی دانش اعتیاد
  • کد COI اختصاصی: KAMED13_331
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 295
دانلود فایل این مقاله

نویسندگان

Samira Khani

neuroscience research center, Qom University of Medical Sciences, Qom, Iran

Hamid Farahani

Department of physiology, Qom University of Medical Sciences, Qom, Iran

چکیده

Background and Aim : Opioid substitution treatment is the most common and most effective modality for the treatment of opioid dependence. Sexual dysfunction is a commonly reported side effect of opioid medications specially methadone Methods : This study is a review of the literature on mechanisms of sexual dysfunction in methadone treated patients. The search for articles was performed on the PubMed, Medline, and Google Scholar online databases, using the search terms Sexual dysfunction, , Opioid , Addiction , Methadone Results : Methadone is largely recognized as an effective treatment for opiate-dependent patients. Chronic opioid use suppresses the hypothalamic pituitary gonadal axis resulting in secondary testosterone deficiency known as Opioid-Induced Androgen Deficiency. Persistently, low testosterone levels are associated with adverse musculoskeletal, metabolic, and neuropsychiatric consequences. Also, it causes reduced brain dopaminergic action resulting in significant sexual dysfunction. Increased blood prolactin levels and the effect of its negative feedback on LH release leading to decreased testosterone production too. The meta-analytical pooled prevalence for sexual dysfunction among methadone users was 52% (95% confidence interval (CI) [0.39, 0.65]), whereby the hypoactive sexual desire and low libido were the most prevalent sexual dysfunctions. Conclusion : The authors concluded that long acting preparations (methadone) lead to sustained suppression of the HPG and therefore result in lower testosterone levels

کلیدواژه ها

Sexual dysfunction, , Opioid , Addiction , Methadone

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.