INTENSITY OF PHYSICAL SIGNS OF MORPHINE WITHDRAWAL SYNDROME IS MORE SEVERE DURING THE REST PHASE

  • سال انتشار: 1398
  • محل انتشار: سیزدهمین کنگره بین المللی دانش اعتیاد
  • کد COI اختصاصی: KAMED13_029
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 484
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نویسندگان

Fatemeh Rahmati Dehkordi

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Hossein Azizi

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Behzad Garmabi

Study and Treatment of Circadian Rhythms Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

Saeed Semnanian

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

چکیده

Background and Aim : Many biological events are controlled by the internal clock and exhibit circadian rhythm. Investigations have shown that the circadian rhythm can affect the mechanisms associated with reward so the aim of the current study is to assess the physical signs of morphine withdrawal syndrome during the different circadian time (CT).Methods : Male Wistar rats (250-300 g) were administered 10 mg/kg morphine every 12h, for 10 days (n=20). Control rats received saline with the same protocol (n=20). Thereafter, when they were made dependent on morphine, tested for opioid withdrawal syndrome during day (CT 8-12) and night (CT 20-24).Results : The intensity of physical signs of morphine withdrawal syndrome was more severe during the day or the rest phase compare to the night.Conclusion : It seems that the intensity of opiate withdrawal syndrome is more severe during the rest phase and this must be consider for detoxification of opiate addicts.

کلیدواژه ها

Circadian rhythm, morphine, withdrawal syndrome, rat

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