ALTERATIONS IN BEHAVIOR, STEREOLOGY AND SYNAPTIC TRANSMISSION ALONG WITH DYSREGULATED SIGNALING PATHWAYS IN HIPPOCAMPUS UPON METHAMPHETAMINE ADMINISTRATION

  • سال انتشار: 1398
  • محل انتشار: سیزدهمین کنگره بین المللی دانش اعتیاد
  • کد COI اختصاصی: KAMED13_027
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 524
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نویسندگان

Aysan Khatmi

Neuroscience Lab, Department of Cell Biology And Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences

Abbas Aliaghaei

Neuroscience Lab, Department of Cell Biology And Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences

چکیده

Background and Aim : Methamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of short term, long term and spatial memory. Herein, we explored the changes in behavior, synaptic transmission, hippocampal volume along with gliosis following METH treatment. Methods : Besides, using genome-wide expression profiling, we applied a pathway-based approach to detect significantly dysregulated signaling pathways. Results : In this regard, we found that METH administration interrupts spatial memory and long term potentiation (LTP). Additionally, stereological analysis revealed a significant alteration in hippocampal volume along with increased gliosis upon METH treatment. Conclusion : We also identified several signaling cascades chiefly related to synaptic transmission which were considerably interrupted in the hippocampus of METH-treated rats. Taken together, our data suggests a potential link between behavioral disruptions and dysregulated signaling pathways.

کلیدواژه ها

Methamphetamine; Hippocampus; Neurotransmission; RNA‐seq

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