Investigation of the effect of nano- and micro-encapsulation on the concentration of essential oil (Artemisia dracunculus) during larvicidal bioassay as well as durability of larvicidal activity
- سال انتشار: 1398
- محل انتشار: دومین کنگره بین المللی بیماریهای منتقله بوسیله ناقلین و تغییرات آب و هوایی و چهارمین کنگره ملی حشره شناسی پزشکی ایران
- کد COI اختصاصی: DCME02_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 456
نویسندگان
Assistant professor, Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Professor, Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Professor, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
چکیده
Background: In recent years, essential oil-based larvicides have been introduced as alternatives to industrial ones. However, an appreciable formulation of essential oil with prolonged larvicidal activity has not yet been introduced.Objectives: Investigating the effect of nano- and micro-encapsulation on the concentration of essential oil during larvicidal bioassay as well as durability of larvicidal activity against Anopheles stephensi (Beech strain).Methods: Essential oil of Artemisia dracunculus (Tarragon: TEO) was encapsulated in chitosan nanoparticles using the ion-gelation technique. Physicochemical properties and duration of larvicidal activity of the prepared nanoformulation were investigated.Results: Encapsulation efficiency of the optimum nanoformulations with a particle size of 168±90 nm was calculated as 39.66% using UV-Vis analysis. Encapsulating TEO in chitosan-TPP nanocapsules was shown to increase its activity: perfect larvicidal activity (100% mortality of larvae) continued for 4 days, compared with 2 days for the non-encapsulated form of TEO. Besides, the duration of larvicidal activity of nanoformulation was significantly longer than its corresponding microformulation with the same concentration of ingredients. Furthermore, the concentration of TEO in the solution tests was also monitored, and it was found that the nanoformulation provides a sustained release of TEO. Moreover, there was a logical relationship between larvicidal activity and concentration of TEO in different hours. For instance, the concentration of non-encapsulated TEO at 72 h was 11 μg mL-1 (close to LC50 of TEO: i.e., 11.36 μg mL-1) and observed larvicidal activity was 47%.Conclusion: The prepared nanoformulation could be introduced as an exciting alternative to synthetic larvicides, due to its easy and fast method of preparation and its green constituentsکلیدواژه ها
Nanoencapsulation, Tarragon essential oil, larvicidal activity, Anopheles stephensi, and chitosan nanocapsulesاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.